Nav1.5 blocker

Nav1.5 cardiac sodium channel blocker

Nav1.5 cardiac sodium channel blocker — mechanism peg (Ballicules) — Nav1.5 blocker — mechanism card

Nav1.5 block = class I antiarrhythmic effect
Slowed conduction → QRS widening (PR prolongation also)
Can unmask a Brugada pattern
Overdose: wide-complex ventricular arrhythmia (mechanism of TCA lethality)

Blocks the cardiac Nav1.5 channel → slowed conduction, QRS widening
Distinct from the neuronal sodium lanes — spike-suppressing, late-current and peripheral blockers are separate mechanisms

Blocks the cardiac Nav1.5 channel → slowed conduction, QRS widening
Distinct from the neuronal sodium lanes — spike-suppressing, late-current and peripheral blockers are separate mechanisms

Blocks the cardiac Nav1.5 channel → slowed conduction, QRS widening
Distinct from the neuronal sodium lanes — spike-suppressing, late-current and peripheral blockers are separate mechanisms

Drugs with this mechanism (96)

Ajmaline Amiodarone Amitriptyline Amoxapine Bupropion hydrobromide ER Aprindine Articaine Bupivacaine Bupropion Carbamazepine Carbamazepine ER capsules Chloroquine Chlorpromazine Chlorpromazine injection Cibenzoline Citalopram Clomipramine Cocaine Cyclobenzaprine Desipramine Desmethylclomipramine Dimenhydrinate Diphenhydramine Diphenhydramine injection Disopyramide Doxepin Venlafaxine XR Encainide Carbamazepine ER (Equetro) Eslicarbazepine Ethacizine Flecainide Bupropion XL 450 mg Haloperidol Haloperidol decanoate LAI Haloperidol injection Hydroquinidine Hydroxybupropion Hydroxynefazodone Imipramine Lacosamide Lacosamide ER Lamotrigine XR Lamotrigine Lidocaine topical Lidocaine injection Lithium Loperamide Maprotiline Mepivacaine Methadone Mexiletine Mirtazapine Moricizine Nefazodone Nordoxepin Nortriptyline Phenytoin Pilsicainide Prilocaine Procainamide Procaine Propafenone Propranolol Propranolol ER Protriptyline Topiramate ER (sprinkle) Quetiapine Quinidine Ranolazine Ropivacaine Rufinamide Quetiapine XR Doxepin low-dose (insomnia) Carbamazepine XR Tetracaine Thioridazine Tocainide Topiramate Topiramate ER Tramadol Trazodone Trimipramine Tramadol ER Valproic acid Divalproex DR Divalproex ER Valproate sodium IV Divalproex sprinkle Venlafaxine Bupropion SR Bupropion XL Ziprasidone Ziprasidone IM Zonisamide Bupropion SR (smoking cessation)

All mechanisms · Open NaV1.5 blocker in the interactive console ↗