Lidocaine injection

XYLOCAINE

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Pronunciation: LYE-doe-kayn

Lidocaine injection ballicule: receptor binding, kinetics and half-life diagram — Mechanism of action: Lidocaine injection ballicule

Lidocaine injection XYLOCAINE mascot mnemonic cartoon — Visual mnemonic: Lidocaine injection mascot
**“Lit up Xylo cane”**

What it isPeripheral and cardiac sodium-channel blocker; local or regional anesthesia and acute ventricular arrhythmias.

Why this oneIt uniquely combines local anesthetic use with intravenous class Ib antiarrhythmic action.

What limits itIntravascular injection or excess exposure causes tinnitus, circumoral numbness, seizures, then cardiovascular collapse.

Lidocaine injection molecular structure (skeletal formula) — Molecular structure: Lidocaine injection

FDA label

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FDA dosing	Population	Start	Target	Max
Local or regional anesthesia (infiltration, peripheral nerve block, epidural)	Adults		Individualized by procedure/site (e.g., ~2–3 mL per dermatome for epidural); use lowest effective dose

Renal Undefined.

Hepatic Use with caution in hepatic disease; severe hepatic disease increases risk of toxic plasma concentrations.

Instructions

Reduce doses for children, elderly/debilitated patients, and those with cardiac or liver disease
Use a test dose (e.g., 2–3 mL of 1.5%) for epidural blocks
Aspirate before and during injection; have resuscitative equipment available

Available strengths

inj 5, 10, 15, 20 mg/mL
granules 100 kg/100 kg
drops 40 mg/mL
emulsion 5 g/100 mL
sol 2, 4 %
cream 0.5 g/10 g
cream 2, 3.9, 4, 5 g/100 g
cream 1.4 g/28 g
+ 34 other marketed forms not shown

Contraindications

Hypersensitivity to amide-type local anesthetics

Cautions

Dose-related CNS and cardiovascular toxicity
Methemoglobinemia
Caution in hepatic and impaired cardiovascular function
Not for intra-articular continuous infusion (chondrolysis)

Adverse reactions

CNS excitation/depression (lightheadedness, tremors, seizures)
Bradycardia
Hypotension
Cardiovascular collapse
Allergic/anaphylactoid reactions

Pregnancy Undefined.

Lactation Undefined.

Cost

Lidocaine injection (XYLOCAINE)

Strength		#/mo	CostPlus
8 mg/mL	inj	per unit	not offered
15 mg/mL	inj	per unit	not offered
40 mg/mL	inj	per unit	not offered

NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. Lidocaine injection is administered under clinical supervision and dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.

Other forms: Lidocaine (XYLOCAINE)

NO BOXED WARNINGS

Principal riskSystemic toxicity (seizures, cardiac arrest) from high levels or intravascular injection; methemoglobinemia

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

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