Eslicarbazepine

APTIOM

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Pronunciation: es-li-kar-BAZ-e-peen (ap-TEE-om)

Eslicarbazepine ballicule: receptor binding, kinetics and half-life diagram — Mechanism of action: Eslicarbazepine ballicule

Eslicarbazepine APTIOM mascot mnemonic cartoon — Visual mnemonic: Eslicarbazepine mascot
**“Slick car App time”**

What it isSodium channel blocker related to oxcarbazepine; focal seizures.

Why it mattersOnce-daily dosing, which oxcarbazepine does not offer.

What it changesHyponatremia as for the family. Renally adjusted; serious skin reactions.

Eslicarbazepine molecular structure (skeletal formula) — Molecular structure: Eslicarbazepine

FDA-approved for

partial-onset seizures (2013)

Off-label

trigeminal neuralgia

FDA label

Read the full label on DailyMed ↗

FDA dosing	Population	Start	Target	Max
Partial-onset seizures (monotherapy or adjunctive)	Adults	400 mg QD (or 800 mg QD if needed)	800-1600 mg QD	1600 mg QD
Partial-onset seizures (monotherapy or adjunctive)	Peds 4-17 y	Weight-based QD	Weight-based maintenance QD	1600 mg QD

Titration Increase in weekly increments of 400-600 mg

Renal Reduce dosage by 50% for moderate or severe renal impairment

Hepatic Undefined

Instructions

Take whole or crushed, with or without food
Withdraw gradually to minimize risk of increased seizure frequency/status epilepticus

Available strengths

tab 200, 400, 600, 800 mg

Contraindications

Hypersensitivity to oxcarbazepine (cross-reactivity)

Cautions

Suicidal behavior and ideation
Serious dermatologic reactions and DRESS
Anaphylactic reactions and angioedema
Hyponatremia
Neurological effects (dizziness, gait/coordination disturbance, somnolence, cognitive dysfunction, visual changes)
Gradual withdrawal required
Drug-induced liver injury
Hematologic reactions (pancytopenia, agranulocytosis, leukopenia)

Adverse reactions

Dizziness
Somnolence
Nausea
Headache
Diplopia
Vomiting
Fatigue
Vertigo
Ataxia
Blurred vision
Tremor

Pregnancy Animal studies show developmental toxicity/malformations; may cause fetal harm

Lactation Undefined

Cost

Eslicarbazepine (APTIOM)

What pharmacies pay · NADAC 9/30/26

Strength		#/mo	generic $/mo	CostPlus
200 mg	tab	30 qd	$50.27	offered
400 mg	tab	30 qd	$55.52	offered
600 mg	tab	30 qd	$69.71	offered
800 mg	tab	30 qd	$51.77	offered

Generic entry2021

NO BOXED WARNINGS

Principal riskHyponatremia

Classes and tags

Clinical profile

Therapeutic safety burden2 / 4

Overdose danger2 / 4

Weight-gain liability1 / 4

Sedation liability1 / 4

QT / Torsades0 / 4

Direct muscarinic antagonism0 / 4

Embryofetal risk2 / 4

Legacy pregnancy categoryC

Defining liabilitySedation, dizziness and agent-specific rash, behavioral, hepatic, hematologic or teratogenic toxicity.

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Memory aids: interaction avatars

CYP3A4 inducer (moderate)

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