Not available in the U.S.
Cibenzoline
CIPRALAN
What it isClass IA antiarrhythmic; arrhythmias and hypertrophic obstructive cardiomyopathy in Japan.
Why this oneIts negative inotropy is used deliberately in HOCM, as disopyramide is elsewhere.
What limits itHypoglycemia through KATP blockade, which is unusual for an antiarrhythmic. Not US-approved.
FDA-approved for
- cardiac arrhythmias (non-US)
Off-label
- arrhythmias (approved in Japan and France)
NO BOXED WARNINGS
Principal riskHypoglycemia through KATP blockade, which is unusual for an antiarrhythmic