Not available in the U.S.
Aprindine
FIBORAN
What it isClass I antiarrhythmic; arrhythmias.
Why this oneRetained in some markets for refractory arrhythmia.
What limits itAgranulocytosis and hepatotoxicity; now rarely used. Not US-approved.
FDA-approved for
- cardiac arrhythmias (non-US)
Off-label
- arrhythmias (approved in Japan)
NO BOXED WARNINGS
Principal riskAgranulocytosis and hepatotoxicity; now rarely used