Maprotiline
LUDIOMIL
Pronunciation: ma-PROE-ti-leen
“Map, rotating Lude milf”
tricycles → tricyclic antidepressant (TCA)
What it isTetracyclic noradrenergic reuptake inhibitor; depression.
Why this oneHighly selective for norepinephrine with less anticholinergic burden than the tricyclics.
What limits itThe highest seizure risk of the antidepressants, particularly on rapid titration and in overdose. Long half-life.
FDA-approved for
- depression (~1980)
⚠ BOXED WARNING
- Suicidal thoughts and behaviors in patients under 25
Classes and tags
Clinical profile
Legacy pregnancy categoryB
Defining liabilitySeizures, anticholinergic effects and cardiotoxic overdose
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