Tocainide
TONOCARD
What it isOral class IB antiarrhythmic, a lidocaine analogue; withdrawn.
Why this oneIt offered oral lidocaine-like activity for ventricular arrhythmia.
What limits itAgranulocytosis and pulmonary fibrosis ended its use.
FDA-approved for
- ventricular arrhythmias (withdrawn) (1984)
⚠ BOXED WARNINGS
- Agranulocytosis
- Pulmonary fibrosis
Classes and tags
Clinical profile
Defining liabilityPotentially fatal marrow and pulmonary toxicity