Alpha-1 antagonist

Alpha-1 adrenergic receptor antagonist

Alpha-1 adrenergic receptor antagonist — mechanism peg (Ballicules) — Alpha-1 antagonist — mechanism card

Sympatholytic → removes “fight or flight”
If BBB-crossing: ↓ PTSD hyperarousal/nightmares
Orthostasis/first-dose syncope
Relaxes prostate/bladder neck → improves BPH

Alpha-1 antagonist (1/2)

Sympatholytic – removes “fight or flight”
↓ BP, orthostatic hypotension
➔ risk of first-dose syncope
Relaxation of bladder neck and prostate
↓ hyperarousal and nightmares in PTSD for those that cross blood-brain barrier

Alpha-1 antagonist (2/2)

➔ can be titrated more quickly without syncope risk
Uncommonly, retrograde ejaculation or priapism
➔ hypertensive emergency
➔ rescue of local extravasation of vasopressors

Drugs with this mechanism (93)

8-OH-Amoxapine Loxapine inhaled Alfuzosin Amitriptyline Amoxapine Aripiprazole Aripiprazole lauroxil LAI Aripiprazole lauroxil LAI Aripiprazole monohydrate LAI Aripiprazole monohydrate LAI Asenapine Asenapine transdermal Brexpiprazole Carvedilol Chlorpromazine Chlorpromazine injection Clomipramine Clozapine Cyclobenzaprine Cyproheptadine Dehydroaripiprazole Desipramine Desmethylclomipramine (Desmethyl-) mirtazapine Doxazosin Doxepin Doxylamine Droperidol Clozapine ODT Fluphenazine Fluphenazine decanoate LAI Haloperidol Haloperidol decanoate LAI Haloperidol injection Hydroxynefazodone Hydroxyzine HCl Hydroxyzine IM Hydroxyzine pamoate Iloperidone Imipramine Labetalol Loxapine Lumateperone Lurasidone Maprotiline Melperone Mianserin Milsaperidone Mirtazapine Molindone Nefazodone Norclozapine Nordoxepin Norquetiapine Nortriptyline Olanzapine Olanzapine IM Olanzapine pamoate LAI Olanzapine SubQ LAI Paliperidone Paliperidone palmitate LAI Paliperidone palmitate LAI Paliperidone palmitate LAI Paliperidone palmitate LAI Perphenazine Phenoxybenzamine Phentolamine Pimozide Prazosin Prochlorperazine Promethazine Promethazine injection Protriptyline Quetiapine Risperidone Risperidone LAI Risperidone LAI Risperidone LAI Risperidone LAI Risperidone LAI Quetiapine XR Doxepin low-dose (insomnia) Silodosin Tamsulosin Terazosin Thioridazine Thiothixene Trazodone Trifluoperazine Trimipramine Clozapine oral suspension Ziprasidone Ziprasidone IM

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