Doxylamine
UNISOM
Pronunciation: dox-IL-a-meen
What it isFirst-generation H1 antagonist; insomnia, and with pyridoxine for nausea of pregnancy.
Why this oneThe pyridoxine combination is the only FDA-approved treatment for nausea and vomiting of pregnancy.
What limits itAnticholinergic burden and next-day sedation. Tolerance to the hypnotic effect develops quickly.
FDA-approved for
- insomnia (~1948)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Insomnia (OTC nighttime sleep aid) | Adults & children ≥12 y | 1 tablet QHS PRN | 1 tablet QHS | 1 tablet/day |
Renal Undefined
Hepatic Undefined
Instructions
- Take one tablet 30 minutes before going to bed.
- Do not use in children under 12 years of age.
Available strengths
- tab 25 mg
- cap 6.25 mg
- sol 6.25 mg/15 mL
- sol 9.78 mg/3 mL
Pregnancy Undefined
Lactation Undefined
Cost
Doxylamine (UNISOM)
What pharmacies pay · NADAC 9/30/26 · OTC
| Strength | #/mo | generic $/unit | CostPlus | |
|---|---|---|---|---|
| 25 mg | tab | per unit | $0.12/ea | not offered |
NO BOXED WARNINGS
Principal riskAnticholinergic burden and next-day sedation
Classes and tags
Clinical profile
Defining liabilityResidual sedation and antimuscarinic effects