Melperone

What it isMelperone (BURONIL) — atypical antipsychotic of the butyrophenone class, approved in several European countries but never FDA-approved; low-EPS profile used for agitation and psychosis, mostly in older adults; short half-life (~4 h) and clinically relevant CYP2D6 inhibition (TDM: dose-corrected venlafaxine ≈+72%).

Why this oneModerate-to-low-affinity D2 and 5-HT2A antagonism with alpha-1 and H1 blockade — an atypical profile despite its first-generation butyrophenone chemistry.

What limits itNever FDA-approved (ruling 5: shown as N/A); dose-dependent QT prolongation reported in the class — treat like other low-potency antipsychotics for monitoring.