Mianserin
TOLVON
What it isTetracyclic alpha-2 antagonist; depression outside the US.
Why this oneThe predecessor of mirtazapine, sedating and without sexual dysfunction.
What limits itAgranulocytosis is more frequent than with mirtazapine. Not US-approved.
FDA-approved for
- depression (non-US)
Off-label
- depression (approved in Europe and Japan)
⚠ BOXED WARNING
- Suicidal thoughts and behaviors in patients under 25
Classes and tags
Clinical profile
Defining liabilityMarked sedation; potentially severe bone-marrow suppression
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Memory aids: interaction avatars
