Norquetiapine
quetiapine metabolite
“Nora, Quit typing!”
Crown → antihistamine
QT prolongation
Magical orb → NQTP is more relevant than QTP parent
What it isN-desalkylquetiapine, formed by CYP3A4, a norepinephrine reuptake inhibitor and 5-HT1A partial agonist.
Why it mattersIt carries most of quetiapine’s antidepressant effect, which the parent’s receptor profile alone does not explain.
What it changesIt explains why quetiapine works in bipolar depression at doses well below the antipsychotic range.
FDA-approved for
- depression/psychosis (active metabolite of quetiapine)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug