Serotonin reuptake inhibitor
- ↑ extracellular serotonin
- Antidepressant, anxiolytic and anti-obsessional effects
- Sexual dysfunction, GI effects and early activation
- With MAO inhibition → high serotonin-toxicity risk
Serotonin reuptake inhibitor (1/2)
- Inhibits serotonin transporter (SERT)
- Selective serotonin reuptake inhibitors (SSRIs):
- Gillman: only two TCAs with substantial SRI potency
- Atypical antidepressants with SRI as core mechanism:
- Antipsychotics with SRI effect
- <a href="/drug/serotonin/">Serotonicity</a> — how much a drug raises synaptic serotonin, and why "serotonergic" is not the same thing
Serotonin reuptake inhibitor (2/2)
- Other drugs with meaningful SRI potency (Gillman):
Drugs with this mechanism (58)
8-OH-Amoxapine
Amitriptyline
Amoxapine
Atomoxetine
Brompheniramine
Centanafadine
Chlorpheniramine
Chlorpromazine
Chlorpromazine injection
Citalopram
Clomipramine
Cocaine
Desipramine
Desmethylclomipramine
Desmethylsertraline
Desvenlafaxine
Dextromethorphan
Dextrorphan
Doxepin
Duloxetine
Venlafaxine XR
Escitalopram
Fluoxetine
Fluvoxamine
Hydroxynefazodone
Ibogaine
Imipramine
Levomilnacipran
Levorphanol
Lumateperone
Fluvoxamine CR
Meperidine
Methadone
Milnacipran
Nefazodone
Nordoxepin
Norfluoxetine
Noribogaine
Nortriptyline
Paroxetine
Paroxetine CR
Pentazocine
Protriptyline
R-Methadone
Saffron
Sertraline
Doxepin low-dose (insomnia)
St John's wort
Tapentadol
Tramadol
Trazodone
Trimipramine
Tramadol ER
Venlafaxine
Vilazodone
Vortioxetine
Ziprasidone
Ziprasidone IM
All mechanisms · Open SERT inhibitor in the interactive console ↗