Dextrorphan
dextromethorphan metabolite
What it isThe O-demethyl metabolite of dextromethorphan, a more potent NMDA antagonist than the parent.
Why it mattersIt produces the dissociative effects of dextromethorphan, which is why CYP2D6 ultra-rapid metabolizers experience them at lower doses.
What it changesBlocking its formation with quinidine or bupropion is the basis of the dextromethorphan combination antidepressants.
FDA-approved for
- cough (metabolite of dextromethorphan)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug