5-HT2C antagonist
5-HT2C serotonin receptor antagonist
- Removes serotonin’s appetite-suppressing brake → weight gain
- “I’d like to see (2C) my feet”
- ↑ frontal dopamine and norepinephrine → activating antidepressant effect
- Removes serotonin’s appetite-suppressing brake
- Contributor to weight gain when in context of D2 blockade (Kirk et al, 2009)— “I’d like ‘2C’ my feet”
- Possible amplification of H1-antagonist-induced weight gain
- ↑ DA and NE activity in frontal cortex
- ➔ “activating” antidepressant effect
Drugs with this mechanism (51)
8-OH-Amoxapine
Loxapine inhaled
Amitriptyline
Amoxapine
Asenapine
Asenapine transdermal
Chlorpromazine
Chlorpromazine injection
Clozapine
Cyproheptadine
Desipramine
(Desmethyl-) mirtazapine
Doxepin
Clozapine ODT
Flibanserin
Fluoxetine
Hydroxynefazodone
Imipramine
Loxapine
Mianserin
Mirtazapine
Nefazodone
Norclozapine
Nordoxepin
Norfluoxetine
Norquetiapine
Nortriptyline
Olanzapine
Olanzapine IM
Olanzapine pamoate LAI
Olanzapine SubQ LAI
Paliperidone
Paliperidone palmitate LAI
Paliperidone palmitate LAI
Paliperidone palmitate LAI
Paliperidone palmitate LAI
Pimavanserin
Protriptyline
Risperidone
Risperidone LAI
Risperidone LAI
Risperidone LAI
Risperidone LAI
Risperidone LAI
Doxepin low-dose (insomnia)
Trazodone
Trimipramine
Clozapine oral suspension
Viloxazine
Ziprasidone
Ziprasidone IM
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