COX-2 inhibitor
Cyclooxygenase-2 inhibitor
- The inducible inflammatory isoform
- ↓ inflammatory prostaglandins → analgesic/anti-inflammatory effect
- Spares platelet COX-1 unless paired with COX-1 inhibition
- Shifts the prostacyclin/thromboxane balance toward thrombosis
- Anti-inflammatory and analgesic with less GI toxicity than COX-1
- Cardiovascular risk with selective agents
Drugs with this mechanism (28)
Aspirin
Bromfenac
Diclofenac oral solution
Celecoxib
Diclofenac
Diclofenac topical gel
Diflunisal
Etodolac
Etoricoxib
Fenoprofen
Diclofenac topical patch
Flurbiprofen
Ibuprofen
Imrecoxib
Indomethacin
Ketoprofen
Ketorolac
Meclofenamate
Mefenamic acid
Meloxicam
Naproxen
Oxaprozin
Piroxicam
Salicylate
Salsalate
6-MNA
Sulindac sulfide
Tolmetin
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