Ibuprofen
MOTRIN, ADVIL
Pronunciation: eye-BYOO-proe-fen
“I be pro-Moat in Ad-Ville”
“The N said... NSAID”
What it isNonselective COX-1 and COX-2 inhibitor; pain, fever and inflammation.
Why this oneShort action and pediatric liquid formulations make it the flexible OTC NSAID for fever and brief pain.
What limits itGI bleeding, kidney injury and cardiovascular risk rise with exposure. Taken before aspirin it can blunt platelet effect; lithium also rises.
FDA-approved for
- pain/inflammation (1974)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Pain/fever (OTC, weight- or age-based) | Children | 24–35 lb (2–3 yr): 1 tab; 36–47 lb (4–5 yr): 1½ tab; 48–59 lb (6–8 yr): 2 tab; 60–71 lb (9–10 yr): 2½ tab; 72–95 lb (11 yr): 3 tab | 4 doses/day |
Renal Undefined
Hepatic Undefined
Repeat every 6–8 hours as needed; do not use more than 4 times a day
Instructions
- Chew or crush tablets completely before swallowing
- Use weight to dose if possible, otherwise age
- Under 24 lb / under 2 yr: ask a doctor
- Do not give more than directed
Available strengths
- tab 200, 400, 600, 800 mg (200 OTC)
Pregnancy Undefined
Lactation Undefined
Cost
Generic entry1985
⚠ BOXED WARNINGS
- Cardiovascular thrombotic events
- Gastrointestinal bleeding, ulceration and perforation
Classes and tags
Clinical profile
Legacy pregnancy categoryMultiple / indication-, trimester- or formulation-dependent
Defining liabilityGI bleeding, kidney injury, hypertension and fluid retention; many agents increase lithium concentrations.
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