6-MNA
from nabumetone
What it is6-methoxy-2-naphthylacetic acid, the active metabolite of nabumetone; arthritis.
Why it mattersThe parent is a non-acidic prodrug, which is the basis of nabumetone’s claimed gastric sparing.
What it changesOnce formed it carries the full NSAID GI, renal and cardiovascular risk. A long half-life prolongs any toxicity.
NO BOXED WARNINGS
Principal riskFull NSAID risk once formed; long half-life