Sulindac sulfide
from sulindac
What it isThe active sulfide metabolite of sulindac, a COX inhibitor; arthritis.
Why it mattersReversible reduction from the inactive sulfoxide gives sulindac its long duration.
What it changesStandard NSAID risk once formed. ⛑ Sulindac is the NSAID that does NOT raise lithium, because the parent is inactive.
NO BOXED WARNINGS
Principal riskStandard NSAID GI and renal risk