COX-1 inhibitor
Cyclooxygenase-1 inhibitor
- The constitutive housekeeping isoform
- ↓ protective gastric prostaglandins → ulcer/bleeding risk
- ↓ platelet thromboxane A2 → antiplatelet effect
- Reduces protective gastric prostaglandins
- ➔ GI ulceration and bleeding risk
Drugs with this mechanism (26)
Aspirin
Bromfenac
Diclofenac oral solution
Celecoxib
Diclofenac
Diclofenac topical gel
Diflunisal
Etodolac
Fenoprofen
Diclofenac topical patch
Flurbiprofen
Ibuprofen
Indomethacin
Ketoprofen
Ketorolac
Meclofenamate
Mefenamic acid
Meloxicam
Naproxen
Oxaprozin
Piroxicam
Salicylate
Salsalate
6-MNA
Sulindac sulfide
Tolmetin
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