Muscle nAChR antagonist
Muscle-type nicotinic acetylcholine receptor antagonist
- Competitive block → non-depolarizing paralysis
- Surgical neuromuscular blockade
- Reversed by acetylcholinesterase inhibition
- No sedation or analgesia → awareness risk without anesthesia
- Competitive blockade of neuromuscular junction → flaccid paralysis
- Non-depolarizing neuromuscular blockers
- Most contain “cur” in the name
Drugs with this mechanism (8)
- Atracurium — Nondepolarizing neuromuscular blocker cleared by Hofmann elimination.
- Cisatracurium — Nondepolarizing neuromuscular blocker cleared organ-independently.
- Curare — The original nondepolarizing neuromuscular blocker (tubocurarine).
- Metocurine — Obsolete nondepolarizing neuromuscular blocker.
- Mivacurium — Short-acting nondepolarizing neuromuscular blocker.
- Pancuronium — Long-acting nondepolarizing neuromuscular blocker.
- Rocuronium — Rapid-onset nondepolarizing neuromuscular blocker; reversed by sugammadex.
- Vecuronium — Intermediate-acting nondepolarizing neuromuscular blocker.
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