Curare
d-tubocurarine
What it isThe original non-depolarizing nicotinic antagonist.
Why this oneIt is the compound that made modern anesthesia possible by separating paralysis from depth of anesthesia.
What limits itHistamine release and ganglionic blockade caused hypotension, which is why it was replaced. Of historical interest only.
NO BOXED WARNINGS
Principal riskHistorical only; hypotension from histamine and ganglionic block