Metocurine
METUBINE
What it isNon-depolarizing neuromuscular blocker; historical surgical paralysis.
Why this oneA methylated curare derivative with less histamine release than tubocurarine.
What limits itSuperseded entirely by the aminosteroid and benzylisoquinolinium agents.
FDA-approved for
- neuromuscular blockade (surgery) (1948)
NO BOXED WARNINGS
Principal riskHistorical; histamine release
Classes and tags
Clinical profile
Defining liabilityRespiratory paralysis requiring mechanical ventilation