Pancuronium

PAVULON

What it isLong-acting competitive muscle nicotinic-receptor antagonist; prolonged surgical paralysis.

Why this oneVagolytic tachycardia distinguishes it from hemodynamically quieter modern neuromuscular blockers.

What limits itRenal accumulation can prolong blockade; use nerve-stimulator monitoring, and remember paralysis provides no sedation or analgesia.

FDA-approved for

NO BOXED WARNINGS

Principal riskProlonged block in renal failure; no sedation

Therapeutic safety burden3 / 4

Overdose danger4 / 4

Sedation liability0 / 4

Direct muscarinic antagonism0 / 4

Embryofetal risk1 / 4

Legacy pregnancy categoryC

Defining liabilityRespiratory paralysis without unconsciousness; prolonged block and tachycardia