Alpha-2C antagonist
Alpha-2C adrenergic receptor antagonist
- Removes inhibitory feedback on monoamine release
- If BBB-crossing: may enhance cortical catecholamine tone and cognition
- Possible ↓ akathisia
- Possible cognitive benefits
- Appetite stimulation (modest effect)
- May potentiate saliva production caused by muscarinic agonists
- ➔ proposed contributor of clozapine-induced hypersalivation
Drugs with this mechanism (26)
1-PP
Asenapine
Asenapine transdermal
Brexpiprazole
Clozapine
Clozapine ODT
Iloperidone
Lurasidone
Mianserin
Mirtazapine
Mitragynine
Paliperidone
Paliperidone palmitate LAI
Paliperidone palmitate LAI
Paliperidone palmitate LAI
Paliperidone palmitate LAI
Phenoxybenzamine
Phentolamine
Risperidone
Risperidone LAI
Risperidone LAI
Risperidone LAI
Risperidone LAI
Risperidone LAI
Clozapine oral suspension
Yohimbine
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