Yohimbine
YOCON
What it isAlpha-2 antagonist; historical use in erectile dysfunction, sold as a supplement.
Why this oneBlocking presynaptic alpha-2 raises noradrenergic outflow, which is why it provokes anxiety experimentally.
What limits itAnxiety, hypertension and tachycardia. Supplement content is wildly variable; interactions with MAOIs and tricyclics.
FDA-approved for
- erectile dysfunction (prescription approval lapsed; now a supplement)
NO BOXED WARNINGS
Principal riskAnxiety, hypertension and tachycardia
Classes and tags
Clinical profile
Defining liabilityAdrenergic stimulation and unpredictable exposure