Mitragynine
in kratom
“My tragic Crater”
What it isThe principal kratom alkaloid, a mu partial agonist biased away from beta-arrestin.
Why this oneIts biased signaling is the pharmacological basis for the claim of analgesia with less respiratory depression.
What limits itIts metabolite 7-hydroxymitragynine is far more potent, so concentrated products behave very differently from leaf.
FDA-approved for
- primary kratom alkaloid (not approved)
NO BOXED WARNINGS
Principal riskIts metabolite 7-hydroxymitragynine is far more potent, so concentrated products behave very dif
Classes and tags
Clinical profile
Active metabolites
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