Serotonin releaser
- Reverses the serotonin transporter → serotonin floods out independent of firing
- High serotonin-toxicity risk, especially with MAO inhibition
- Drives serotonin out of the terminal
- High serotonin toxicity risk, especially with MAO inhibitors
- <a href="/drug/serotonin/">Serotonicity</a> — how much a drug raises synaptic serotonin, and why "serotonergic" is not the same thing
Drugs with this mechanism (10)
- Mixed amphetamine salts XR — Extended-release stimulant for ADHD; long coverage with Schedule II misuse risk.
- Amphetamine XR-ODT — Extended-release orally disintegrating amphetamine for ADHD; no pill swallowing needed.
- Mixed amphetamine salts — Monoamine-releasing stimulant for ADHD and narcolepsy; effective but readily misused.
- Amphetamine XR suspension — Extended-release liquid amphetamine for ADHD; useful when pills are difficult.
- Amphetamine racemic (1:1) — Racemic amphetamine for ADHD; more peripheral sympathomimetic effect than dextro-rich products.
- Fenfluramine — Serotonin releaser once in "fen-phen"; now for Dravet seizures, valvulopathy risk.
- Methylenedioxymethamphetamine — Serotonin releaser (empathogen) under study for PTSD.
- Mephedrone — Synthetic cathinone ("meow meow") stimulant; a monoamine releaser.
- Methamphetamine — Potent, CNS-penetrant amphetamine; high addiction liability, rare medical use.
- Mixed amphetamine salts (triple-bead) — Triple-bead extended-release mixed amphetamine salts for all-day ADHD coverage.
All mechanisms · Open Serotonin releaser in the interactive console ↗