Amphetamine XR suspension

FDA label

Read the full label on DailyMed ↗

Titration Increase in increments of 2.5 to 10 mg/day every 4 to 7 days

Renal Undefined

Hepatic Undefined

Instructions

• Administer orally once daily in the morning, with or without food
• Extended-release oral suspension: shake bottle well before each dose; use the provided oral dosing dispenser
• Extended-release tablets: may be chewed or swallowed whole (5 mg tablet is scored, divisible to 2.5 mg)
• Oral suspension and tablets are substitutable on a mg-per-mg basis; do not substitute mg-per-mg for other amphetamine products
• Assess for cardiac disease and screen for tics/Tourette's before initiating
• Urinary alkalinizers raise, acidifiers lower amphetamine levels — adjust dose accordingly

Available strengths

• ER tab 5, 10, 15, 20 mg
• ER susp 2.5 mg/mL

Contraindications

• Concomitant use of an MAOI, or within 14 days of stopping an MAOI, because of increased risk of hypertensive crisis

Cautions

• Serious cardiac disease — avoid in structural cardiac abnormalities, cardiomyopathy, serious arrhythmia, CAD; sudden death reported
• Increased blood pressure and heart rate
• Psychiatric reactions (exacerbation of psychosis, induction of mania, new psychotic/manic symptoms)
• Long-term growth suppression in pediatric patients — monitor height/weight
• Peripheral vasculopathy, including Raynaud's phenomenon
• Serotonin syndrome with serotonergic drugs/CYP2D6 inhibitors
• Motor and verbal tics; worsening of Tourette's syndrome

Adverse reactions

• Dry mouth
• Anorexia
• Weight loss
• Abdominal pain
• Nausea
• Insomnia
• Restlessness
• Emotional lability
• Dizziness
• Tachycardia
• Epistaxis

Pregnancy Limited data insufficient to determine risk; may cause IUGR and premature delivery; monitor neonates for withdrawal

Lactation Amphetamine present in human milk; breastfeeding not recommended during treatment