OX1 agonist
Orexin-1 receptor agonist
- Promotes arousal, motivation and hedonic feeding
- Part of the wake/reward orexin system
- Wakefulness & arousal (OX1 < OX2)
- ↑ motivation / reward drive
- ↑ hedonic feeding (animal models)
- ↑ physical activity / energy expenditure
Drugs with this mechanism (2)
- Orexin A — Wake-promoting hypothalamic peptide (hypocretin); its loss causes narcolepsy.
- Orexin B — Wake-promoting hypothalamic neuropeptide with relative preference for orexin-2 receptors; an endogenous signal, not a prescribed drug.
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