Orexin A
Hypocretin-1
“Oreo”
What it isEndogenous hypothalamic peptide maintaining wakefulness.
Why this oneIts loss causes narcolepsy type 1, and blocking it is how the -orexant hypnotics work.
What limits itOrexin AGONISTS for narcolepsy are in trials; nothing is yet approved.
NO BOXED WARNINGS
Principal riskIt cannot be given as a drug; agonists are in development for narcolepsy