Orexin B
Hypocretin-2
“Oreo”
What it isHypothalamic neuropeptide (hypocretin-2), cut from the same precursor as orexin A; promotes and stabilizes wakefulness.
Why this oneIt acts preferentially at OX2 receptors. The dual orexin receptor antagonists used for insomnia block both receptors.
What limits itLoss of orexin neurons causes narcolepsy type 1. A physiological signal, not a prescribed drug.
NO BOXED WARNINGS