Alpha-2B antagonist
Alpha-2B adrenergic receptor antagonist
- Mild vasodilation
- Little central effect — the action is vascular
- Mild vasodilation at most
- No major CNS role for α2B receptors
Drugs with this mechanism (5)
- Mirtazapine — Sedating, appetite-stimulating noradrenergic/serotonergic agent; known for weight gain.
- Mitragynine — The main alkaloid of kratom; a mu-opioid partial agonist.
- Phenoxybenzamine — Irreversible alpha blocker for pheochromocytoma.
- Phentolamine — Reversible alpha blocker for pheochromocytoma and vasopressor extravasation.
- Yohimbine — Alpha-2 antagonist supplement; raises noradrenaline and anxiety.
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