Y2 agonist
Neuropeptide Y2 receptor agonist
- Presynaptic NPY autoreceptors
- Feedback inhibition of NPY and norepinephrine release
- Roles in appetite/energy balance
- Opposes postsynaptic Y1 signaling
- Presynaptic autoreceptor — feedback inhibition of NPY and noradrenaline release
- Contrasts with postsynaptic Y1, which mediates anxiolysis and vasoconstriction
- Appetite and energy-balance signaling from the arcuate nucleus
Drugs with this mechanism (2)
- Neuropeptide Y — Abundant CNS peptide; a powerful stimulant of appetite.
- PYY (3-36) — Ileal-brake satiety peptide acting at Y2 — NPY’s counterpart.
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