Neuropeptide Y
endogenous
What it isEndogenous peptide and one of the most powerful orexigenic signals in the brain.
Why this oneIt is a central driver of feeding and stress resilience, which is why Y receptor ligands were pursued for obesity and PTSD.
What limits itNo approved drug targets it; peptide delivery has been the barrier.
NO BOXED WARNINGS
Principal riskNo drug has succeeded against it; receptor redundancy has defeated the approach