PXR agonist
Pregnane X receptor agonist
- Induces CYP3A4 and P-glycoprotein → accelerates clearance of many co-administered drugs
- Activates PXR, inducing CYP3A4 and P-gp
- The mechanism behind St John wort interactions
Drugs with this mechanism (1)
- Hyperforin — St John's wort constituent; a potent PXR agonist driving CYP3A induction.
All mechanisms · Open PXR agonist in the interactive console ↗