Hyperforin
SJW constituent
What it isSt John’s wort constituent and a potent PXR agonist.
Why this oneIt is the reason St John’s wort is a clinically important drug interaction, not the antidepressant effect.
What limits itIt strongly induces CYP3A4 and P-gp, so contraceptives, transplant drugs and anticoagulants fail.
FDA-approved for
- St John's wort constituent (not approved)
Off-label
- St John's wort constituent studied for depression
NO BOXED WARNINGS
Principal riskStrong CYP3A4 and P-gp induction; contraceptives fail