PPAR-gamma agonist
Peroxisome proliferator-activated receptor gamma agonist
- Adipocyte differentiation → ↑ insulin sensitivity
- Sodium/fluid retention → edema, heart-failure exacerbation
- Weight gain
- Improves insulin sensitivity in adipose tissue
- Weight gain, edema, heart failure risk
- Fracture risk in women
Drugs with this mechanism (7)
- EXP3179 — Losartan's aldehyde intermediate; no AT1 activity, a PPAR-γ partial agonist / COX-2 inhibitor.
- Lobeglitazone — Thiazolidinedione insulin sensitizer used in some countries; can cause weight gain, edema, and worsen heart failure.
- Mesalamine — Topically acting 5-ASA for ulcerative colitis; delivery system defines the product.
- Mesalamine DR — Delayed-release 5-ASA for ulcerative colitis; formulation governs colonic delivery.
- Pioglitazone — PPAR-gamma insulin sensitizer; weight gain, edema, heart-failure caution.
- Rosiglitazone — PPAR-gamma sensitizer whose cardiovascular concerns curtailed its use.
- Telmisartan — The longest-acting ARB; also a partial PPAR-gamma agonist.
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