NRF2 activator
NRF2 pathway activator
- Induces antioxidant and cytoprotective genes
- Anti-inflammatory in multiple sclerosis and mitochondrial disease
- Activates the antioxidant response pathway
Drugs with this mechanism (3)
- Dimethyl fumarate — Oral MS drug acting through Nrf2; flushing and lymphopenia are the limiting effects.
- Diroximel fumarate — Dimethyl fumarate reformulated for less GI upset; same active metabolite.
- Omaveloxolone — NRF2 activator for Friedreich ataxia; the first disease-specific therapy.
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