NAD: PARP
- Poly(ADP-ribose) chains built from NAD⁺ recruit repair proteins to DNA breaks
- Repair activity can drain the NAD pool during heavy DNA damage
- Connects genotoxic stress to metabolic depletion
- PARP consumes NAD⁺ to build poly-ADP-ribose at DNA breaks; massive damage can crash cellular NAD
Drugs with this mechanism (1)
- NAD — Niacin-derived coenzyme central to cellular redox reactions; also consumed by enzymes involved in DNA repair and signaling.
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