NAD: sirtuins
- Sirtuins use NAD⁺ to deacetylate histones and metabolic proteins
- Links cellular energy state to gene regulation and aging pathways
- Consumed, not just cycled, in these reactions
- Sirtuins SPEND NAD⁺ as a co-substrate to deacetylate — metabolic state wired to gene regulation
Drugs with this mechanism (1)
- NAD — Niacin-derived coenzyme central to cellular redox reactions; also consumed by enzymes involved in DNA repair and signaling.
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