mTOR inhibitor
Mechanistic target of rapamycin inhibitor
- ↓ T-cell activation → immunosuppression
- ↓ cell growth/proliferation → anticancer
- Impaired repair → mouth ulcers, poor wound healing
- Metabolic effects: hyperlipidemia, hyperglycemia
- Blocks mTOR signaling — immunosuppression and antiproliferation
- Impaired wound healing, hyperlipidemia, mouth ulcers
Drugs with this mechanism (3)
- Everolimus — mTOR inhibitor immunosuppressant and anticancer agent.
- Sirolimus — mTOR inhibitor immunosuppressant (rapamycin).
- Temsirolimus — IV mTOR inhibitor for renal cell carcinoma; converts to sirolimus.
All mechanisms · Open mTOR inhibitor in the interactive console ↗