MT2 agonist
MT2 melatonin receptor agonist
- Shifts and stabilizes circadian phase
- The arm most tied to clock timing — used for non-24 sleep-wake disorder
- Circadian stabilization
- Sleep maintenance
- Vasodilation (context-dependent)
- Retinal function
- ➔ supports photoreceptor renewal
Drugs with this mechanism (3)
- Melatonin — OTC pineal hormone used for sleep and circadian shifting.
- Ramelteon — Melatonin-receptor hypnotic with no abuse potential.
- Tasimelteon — Melatonin agonist for non-24-hour sleep-wake disorder in the blind.
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