I2 imidazoline ligand
I2 imidazoline binding-site ligand
- I2 sites: an allosteric region on monoamine oxidase
- Modulates monoamine metabolism
- A role in pain signaling
- Imidazoline binding site on MAO-B — not a classical receptor
- Binding is well described; the clinical effect is not
Drugs with this mechanism (4)
- Clonidine — Central alpha-2 agonist for hypertension, ADHD and withdrawal; sedation and rebound.
- Clonidine ER — Extended-release central alpha-2 agonist for ADHD; sedation and rebound hypertension limit it.
- Clonidine ER suspension — Extended-release clonidine liquid for ADHD; sedation and rebound hypertension shape use.
- Tizanidine — Short-acting alpha-2 agonist for spasticity; hypotension and CYP1A2 interactions.
All mechanisms · Open Imidazoline I2 ligand in the interactive console ↗