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Clonidine ER

KAPVAY

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Pronunciation: KLOE-ni-deen (KAP-vay)

Clonidine ER ballicule: receptor binding, kinetics and half-life diagram
Mechanism of action: Clonidine ER ballicule
Clonidine ER KAPVAY mascot mnemonic cartoon
Visual mnemonic: Clonidine ER mascot
“Capped Clown dines”
orange plus signs → alpha-2 agonist

What it isClonidine ER (KAPVAY, 2010) is a central alpha-2 agonist reducing sympathetic output; nonstimulant ADHD treatment, approved ages: 6-17.

Why this oneDuration of action 12-16 h (Carlat Table 1); it is more sedating and blood-pressure lowering than guanfacine ER, which can help when insomnia accompanies ADHD.

What limits itSomnolence, bradycardia and hypotension limit use; titrate weekly, avoid abrupt stop to prevent rebound hypertension.

Clonidine ER molecular structure (skeletal formula)
Molecular structure: Clonidine ER

FDA-approved for

Available strengths

NO BOXED WARNINGS

Principal riskRebound hypertension on abrupt withdrawal

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

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Memory aids: interaction avatars

Clonidine ER Box: minimal PK interactions avatar mnemonic
Box: minimal PK interactions

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