Capsid inhibitor
HIV capsid inhibitor
- Disrupts uncoating, nuclear import and assembly
- Active against virus resistant to other antiretroviral classes
- Disrupts the HIV capsid at several stages of replication
Drugs with this mechanism (2)
- Lenacapavir — First-in-class HIV capsid inhibitor; twice-yearly dosing for treatment and prevention.
- Lenacapavir (PrEP) — Long-acting capsid inhibitor for HIV PrEP; infrequent injections remove daily adherence.
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