GlyT1 inhibitor
Glycine transporter 1 reuptake inhibitor
- Synaptic glycine rises
- ↑ NMDA-receptor co-agonism → hypothesized to correct hypoglutamatergic states
- ↓ erythroid glycine uptake → ↓ heme precursor (protoporphyrin) synthesis
- Investigational for schizophrenia to improve cognition and negative symptoms (NMDA hypofunction model)
Drugs with this mechanism (3)
- Bitopertin — Investigational GlyT1 inhibitor.
- Iclepertin — Investigational GlyT1 inhibitor for schizophrenia cognition.
- Sarcosine — A GlyT1 inhibitor studied as a schizophrenia adjunct.
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