Sarcosine
N-methylglycine
What it isN-methylglycine, a glycine transporter type 1 inhibitor and NMDA co-agonist.
Why this oneIt raises synaptic glycine, which is the same target the failed GlyT1 drugs pursued.
What limits itHuman evidence is limited to small adjunct trials in schizophrenia. Sold as an unregulated supplement.
Available strengths
- powder 2 g/scoop (trial dose)
NO BOXED WARNINGS
Principal riskHuman evidence is limited to small adjunct trials in schizophrenia
Classes and tags
Clinical profile
Defining liabilityLimited long-term clinical safety and mood-activation uncertainty