Glycine receptor antagonist
- Unopposed motor-neuron firing → rigidity and seizures
- Spasms with a clear sensorium — spinal, not cortical
- Strychnine, picrotoxin
- Hyperexcitability of neurons
- ➔ seizures, muscle rigidity
Drugs with this mechanism (1)
- Strychnine — A glycine-receptor antagonist convulsant poison.
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