Strychnine
rodenticide
What it isCompetitive glycine receptor antagonist; a rodenticide and historical tonic.
Why this oneIt demonstrated glycine’s role as the inhibitory transmitter of the spinal cord.
What limits itRemoving spinal inhibition causes tetanic convulsions with preserved consciousness. No therapeutic use.
NO BOXED WARNINGS
Principal riskRemoving spinal inhibition causes tetanic convulsions with preserved consciousness